Sprague-Dawley rats were infused with sodium salicylate followed by saline, bicarbonate, or carbon dioxide inhalation. Bicarbonate raised the blood pH and lowered the muscle, brain and liver salicylate concentrations compared with the saline controls. Carbon dioxide inhalation produced the opposite effect. Acetazolamide lowered the blood pH, raised the tissue salicylate levels, and increased the toxicity of sodium salicylate. If the systemic acidosis produced by acetazolamide was prevented with bicarbonate, the rise in tissue salicylate was also prevented.
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John B. Hill (1971) studied this question.
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