Review demonstrates the intermediate acidity and structural versatility of chiral carboxylic acids, highlighting their unique utility in enantioselective Brønsted acid catalysis.
's generally lie between those of typical hydrogen bond donors and chiral phosphoric acids, chiral carboxylic acids provide the opportunity to activate a different set of substrates requiring intermediate catalyst acidity. In addition, by taking advantage of judicious catalyst design, the acidity of carboxylic acids can be modulated, for instance by stabilizing the corresponding carboxylate counterion. This review provides an overview of this field, with the aim of highlighting both catalyst design and synthetic applications.
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Min et al. (2017) studied this question.
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