Key result
Surgical valve replacement and phenprocoumon therapy in a 28-year-old male with non-infective endocarditis was complicated by myocardial ischemia, revealing hereditary coagulation disorders.
Case Report (n=1)
Highlights the importance of investigating hereditary coagulation disorders in young patients presenting with non-infective endocarditis and arterial thrombosis, and the need for tailored anticoagulant monitoring.
May warrant coagulopathy screening in young arterial thrombosis cases; hypothesis-generating for tailored Factor II monitoring.
We report a case of a young male who presented with acute limb ischemia after sport. With no prior history of disease, a non-infective endocarditis of the native aortic valve was diagnosed. After surgical valve replacement, the patient suffered from acute myocardial ischemia under phenprocoumon therapy. Anti-coagulant monitoring was subsequently changed to Factor II analysis after a rare Factor VII deficiency and prothrombin mutation (G20210A) was diagnosed.
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Reid et al. (2020) conducted a case report in Noninfective endocarditis and hereditary coagulation disorders (n=1). Surgical valve replacement and phenprocoumon therapy was evaluated. Surgical valve replacement and phenprocoumon therapy in a 28-year-old male with non-infective endocarditis was complicated by myocardial ischemia, revealing hereditary coagulation disorders.
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