Experimental study demonstrates direct synthesis of cycloalkenes from dienes and olefinic ketones via transition-metal alkylidenes, highlighting efficient routes for carbocycle construction.
The development of efficient methods for constructing carbocycles continues to be an important goal of synthetic organic chemistry. One extremely useful approach to the formation of unsaturated carbocycles is the intramolecular dicarbonyl coupling reaction (eq 1). Oftentimes, the substrate employed in this process is generated by oxidation of a diene or of an olefinic ketone. In this communication, we report that transition-metal alkylidenes effect the direct synthesis of unsaturated carbocycles from either of these precursors (eqs 2 and 3).
No takes yet. Share an insight, caveat, or question.
Fu et al. (1993) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: