Key result
Use of tricyclic antidepressants was associated with an increased incidence of non-Hodgkin lymphoma compared with nonuse (adjusted IRR 1.53; 95% CI 1.06-2.21).
Why the study?
Does the use of tricyclic antidepressants increase the incidence of non-Hodgkin lymphoma compared to nonuse?
Cohort (n=43,932)
No
Does the use of tricyclic antidepressants increase the incidence of non-Hodgkin lymphoma compared to nonuse?
Relative Risk: 1.53 (95% CI 1.06–2.21)
Long-term use of tricyclic antidepressants is associated with an increased risk of non-Hodgkin lymphoma.
No takes yet. Share an insight, caveat, or question.
Should not alter TCA prescribing; hypothesis-generating for NHL risk and requires prospective validation.
Dalton et al. (2008) conducted a cohort in Non-Hodgkin lymphoma (n=43,932). Tricyclic antidepressants vs. Nonuse (0 or 1 prescription) was evaluated on Incidence of non-Hodgkin lymphoma (IRR 1.53, 95% CI 1.06-2.21). Use of tricyclic antidepressants was associated with an increased incidence of non-Hodgkin lymphoma compared with nonuse (adjusted IRR 1.53; 95% CI 1.06-2.21).
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