Why the study?
Does acute intravenous labetalol alter haemodynamic and metabolic responses during rest and dynamic forearm exercise in young, healthy male subjects?
Does acute intravenous labetalol alter haemodynamic and metabolic responses during rest and dynamic forearm exercise in young, healthy male subjects?
Acute intravenous labetalol in healthy men reduces arterial blood pressure at rest and alters haemodynamic and metabolic responses during forearm exercise, including decreased forearm blood flow and oxygen uptake.
Answers are grounded in this paper and cite their sources.
Acute labetalol effects in healthy men should not change practice; leaves open impact on exercise capacity in patients with hypertension or HF.
At rest supine acute intravenous administration of the combined adrenergic alpha- and beta-receptor blocking compound labetalol (1 mg/kg body weight) to young, healthy, male subjects, produced a clear-cut fall in arterial blood pressure. During dynamic forearm exercise, forearm blood flow decreased by 17.2%, and calculated vascular resistance increased by 11.3% after labetalol. Forearm oxygen uptake decreased (14.6%), suggesting an increased mechanical efficiency. Lactate release from the exercising forearm decreased (17.6%), probably because of the beta-receptor blockade. Forearm uptake of glucose and free fatty acids remained unchanged. Arterial blood glucose concentration attained a higher level after labetalol. Arterial plasma concentration of FFA was reduced during exercise and post-exercise probably because beta-receptor mediated lipolysis was antagonized.
No takes yet. Share an insight, caveat, or question.
Hartling et al. (1980) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: