Evaluating the visceral adiposity inflammatory index for enhanced stroke risk assessment

Figures

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  Fig. 1. Flowchart of CHARLS participants.

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  Fig. 2. K-M plot of cumulative incidence of new-onset stroke based on VAI, CRP and VAII levels.

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  Fig. 3. Associations of VAII, VAI and CRP with the risk of stroke. Adjusted Model included Age, eGFR (Cystatin C), Depression, Gender, Marital Status, Education Level, Rural Area, Smoking Status, Diabetes, Hypertension, Antidiabetic Medication, Antihypertensive Medication, Drinking Status, Dyslipidemia, Loneliness, Exercise Status, and Heart Disease.

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  Fig. 4. ROC curve and relative importance of VAII, VAI and CRP for predicting stroke. (A) Receiver Operating Characteristic (ROC) curves for VAII, VAI, and CRP were used independently to evaluate their discriminatory ability by calculating the Area Under the Curve (AUC). (B) The base model included the following variables: Age, eGFR (Cystatin C), Depression, Gender, Marital Status, Education Level, Rural Area, Smoking Status, Diabetes, Hypertension, Antidiabetic Medication, Antihypertensive Medication, Drinking Status, Dyslipidemia, Loneliness, Exercise Status, and Heart Disease. Combine VAII, VAI and CRP with the basic model in that order. (C) Relative importance of risk factors for predicting stroke.

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  Fig. 5. Mediation analyses of stroke risk factors. Adjusted for Age, eGFR (Cystatin C), Depression, Gender, Marital Status, Education Level, Rural Area, Smoking Status, Diabetes (with the exception of the FBG model), Hypertension (with the exception of the SBP and DBP models), Antidiabetic Medication, Antihypertensive Medication, Drinking Status, Dyslipidemia, Loneliness, Exercise Status, and Heart Disease. VAII, VAI and CRP were categorized into two groups based on the 50% cut-off. Abbreviations: VAI, visceral adiposity index; CRP, high-sensitivity C-reactive protein; SBP, systolic blood pressure; DBP, diastolic blood pressure; FBG, fasting blood glucose; TyG, triglyceride-glucose index.

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  Fig. 6. Association between cumulative and change in VAII, VAI and CRP and incident stroke. Adjusted Model included Age, eGFR (Cystatin C), Depression, Gender, Marital Status, Education Level, Rural Area, Smoking Status, Diabetes, Hypertension, Antidiabetic Medication, Antihypertensive Medication, Drinking Status, Dyslipidemia, Loneliness, Exercise Status, and Heart Disease.