Key result
Antisera against the PIF binding protein attenuated protein degradation in murine myotubes and decreased body weight loss in mice bearing the MAC16 tumor.
Why the study?
Does antisera against the PIF receptor attenuate muscle atrophy in cachexia models?
Population
Mouse and pig skeletal muscle sarcolemma membranes, murine myoblasts, human muscle cell line, and mice…
Comparison
Antisera reactive to a 19mer from the N-terminal… vs Control/untreated (implied in preclinical models)
Design
Preclinical
Authors
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May offer new cachexia target in models; leaves open human translation.
Does antisera against the PIF receptor attenuate muscle atrophy in cachexia models?
Identification of a DING protein as the PIF receptor provides a potential new therapeutic target for muscle atrophy in cachexia.
Todorov et al. (2007) studied Cachexia and muscle atrophy. Antisera reactive to the PIF binding protein was evaluated on Protein degradation and body weight decrease. Antisera against the PIF binding protein attenuated protein degradation in murine myotubes and decreased body weight loss in mice bearing the MAC16 tumor.
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