Key result
Spontaneously hypertensive rats exhibited significant autonomic dysfunction with sympathetic dominance, as evidenced by a markedly increased centralization index (6.5 vs 0.2) compared to normotensive controls.
Why the study?
The study was conducted to provide a comparative description of the autonomic regulation of heart rhythm between normotensive controls and spontaneously hypertensive rats.
Spontaneously hypertensive rats exhibit significant autonomic dysfunction characterized by sympathetic overactivity and cardiac hypertrophy compared to normotensive controls.
The paper covers a comparative description of the state of autonomic regulation of heart rhythm in purebred white rats, chosen as normotensive controls, and Spontaneously Hypertensive Rats (SHR) s as a model of chronic arterial hypertension. In rats with a normal level of blood pressure, the tone of the autonomic nervous system is shown to be characterized by an eitonic orientation, which indicates the presence of physiological reserves capable of maintaining circulatory homeostasis. Sustained high blood pressure in 12-month-old SHR leads to a marked (by 30%) rise in the relative weight of the heart compared to controls, that indicates the development of cardiac hypertrophy in spontaneously hypertensive rats and the risk of developing cardiovascular diseases in them. In this group of rats, changes in the vegetative balance were also found, and they were expressed in the low synchronization of regulatory components and the growth of the regulation sympathetic link. The experimental data obtained during the analysis of heart rate variability demonstrate the presence of phenomena of overstrain and asthenia in the regulatory compartments of the central nervous system in rats with chronic arterial hypertension, which over time can result in manifestations of the hypertensive form of dyscirculatory encephalopathy and premature aging.
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Бабийчук et al. (2024) studied Chronic arterial hypertension (n=18). Spontaneous hypertension (SHR strain) vs. Normotensive white outbred rats was evaluated on Index of Centralization (IC) of heart rhythm regulation (p=<0.05). Spontaneously hypertensive rats exhibited significant autonomic dysfunction with sympathetic dominance, as evidenced by a markedly increased centralization index (6.5 vs 0.2) compared to normotensive controls.
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