Key result
In patients with severe sepsis or septic shock, myocardial PARP activation positively correlated with troponin I levels (r2 = 0.73; p < .05) and was associated with significant myocardial damage.
Why the study?
Does PARP activation correlate with myocardial contractile dysfunction and necrosis in patients with severe sepsis or septic shock?
Observational (n=25)
No
Does PARP activation correlate with myocardial contractile dysfunction and necrosis in patients with severe sepsis or septic shock?
Effect estimate: r2 = 0.73
p-value: p=<.05
PARP activation is significantly present in the hearts of septic patients with impaired cardiac function and correlates with troponin I levels, suggesting a role in sepsis-induced cardiac depression.
Supports PARP as mediator of septic myocardial injury; leaves open whether inhibition preserves function in shock.
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Soriano et al. (2006) conducted an observational in Severe sepsis or septic shock (n=25). Severe sepsis or septic shock vs. Survivors was evaluated on Correlation between PAR staining densitometry and troponin I (r2 = 0.73, p=<.05). In patients with severe sepsis or septic shock, myocardial PARP activation positively correlated with troponin I levels (r2 = 0.73; p < .05) and was associated with significant myocardial damage.
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