Key result
In vitro fertilization was not associated with a significant difference in fetal right myocardial performance index compared to spontaneous pregnancy (0.42 vs 0.43, p=0.891).
Why the study?
Evaluating whether in vitro fertilization affects fetal cardiac function is important for assessing the safety of the technique.
Does in vitro fertilization affect the fetal right myocardial performance index compared to spontaneous pregnancy?
Cross-Sectional (n=410)
No
Does in vitro fertilization affect the fetal right myocardial performance index compared to spontaneous pregnancy?
In vitro fertilization does not appear to significantly impact fetal right ventricular function as measured by the right myocardial performance index compared to spontaneous pregnancy.
Comparable fetal RMPI in IVF and spontaneous pregnancies; leaves open long-term effects and requires prospective validation.
Background Whether the in vitro fertilization (IVF) has an effect on the cardiac function of the fetus is very important to evaluate the safety of the technique. The aim of this paper is to establish normal reference range for the fetal right myocardial performance index (RMPI), and compare the reference range between IVF fetuses and spontaneous pregnancy (SP) fetuses by automatic measurement of the RMPI.Methods 371 spontaneous singleton pregnancies (the control group) and 39 singleton pregnancies conceived by IVF (the experimental group) were enrolled into the current study. An automatic measurement system was used to acquire the RMPI. The cardiac function of the two groups was compared by t-test. Results There was no significant difference in normal reference range of RMPI between IVF fetuses and SP fetuses (RMPI 0.42 ±0.05 vs 0.43±0.05). No strong correlation was also noted between RMPI with gestational age and heart rate.Conclusions Normal reference ranges of RMPI of IVF fetuses and SP fetuses were established, and no significant difference between IVF fetuses and SP fetuses in RMPI was found. Thus, these findings may suggest that IVF has little impact on cardiac function of the fetus.
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Chen et al. (2021) conducted a cross-sectional in Fetal cardiac function (n=410). In vitro fertilization (IVF) vs. Spontaneous pregnancy was evaluated on Right myocardial performance index (RMPI) (p=0.891). In vitro fertilization was not associated with a significant difference in fetal right myocardial performance index compared to spontaneous pregnancy (0.42 vs 0.43, p=0.891).
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