Key result
Magnesium sulfate seizure prophylaxis in women with severe preeclampsia or eclampsia significantly increased fetal modified myocardial performance index from 0.41 to 0.49 (p<0.05).
Why the study?
The study aimed to investigate the effect of magnesium sulfate seizure prophylaxis on fetal cardiac function in pregnant women diagnosed with severe preeclampsia and eclampsia.
Does magnesium sulfate treatment for seizure prophylaxis affect fetal cardiac function (mod-MPI) in pregnant women with severe preeclampsia or eclampsia?
Observational (n=50)
Does magnesium sulfate treatment for seizure prophylaxis affect fetal cardiac function (mod-MPI) in pregnant women with severe preeclampsia or eclampsia?
Absolute Event Rate: 0.49% vs 0.41%
p-value: p=<0.05
Magnesium sulfate seizure prophylaxis in severe preeclampsia/eclampsia is associated with a significant increase in fetal modified myocardial performance index, suggesting transiently worsened fetal cardiac function.
May alter fetal cardiac function during MgSO4 prophylaxis in severe preeclampsia; leaves open questions on clinical relevance pending prospective trials.
Objective: This study aimed to investigate the effect of magnesium sulfate treatment on fetal cardiac function during seizure prophylaxis of pregnant women diagnosed with severe preeclampsia and eclampsia. Fetal cardiac function was evaluated with the modified myocardial performance index (mod-MPI) before and after prophylaxis. Methods: A total of 50 pregnant women diagnosed with severe preeclampsia or eclampsia were involved. The characteristics of the participants, medical and obstetric history, ultrasound and laboratory findings were recorded. Fetal mod-MPI was obtained before and after magnesium treatment. Data were analyzed with appropriate statistical tests and p < 0.05 was considered to indicate statistical significance . Results: The mean maternal and gestational ages of pregnant women were 31.7 ± 5.9 and 32.4 ± 4.5. Mean mod-MPI before and after prophylaxis were 0.41 ± 0.18 and 0.49 ± 0.09, respectively (p<0.05). Conclusion: There was a significant increase in fetal mod-MPI after magnesium prophylaxis was given to severe preeclampctic/eclamptic women. The higher the mod-MPI, the worse the fetal cardiac function. This might have been the result of magnesium leading to an increased isovolumetric relaxation time.
No takes yet. Share an insight, caveat, or question.
Küçükbaş et al. (2023) conducted an observational in Severe preeclampsia and eclampsia (n=50). Magnesium sulfate seizure prophylaxis vs. Before prophylaxis (baseline) was evaluated on Fetal modified myocardial performance index (mod-MPI) (p=<0.05). Magnesium sulfate seizure prophylaxis in women with severe preeclampsia or eclampsia significantly increased fetal modified myocardial performance index from 0.41 to 0.49 (p<0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: