Key result
Ventricular repolarization parameters did not differ significantly between children with diet-compliant celiac disease and healthy controls, though QTc dispersion was prolonged in patients diagnosed at an older age.
Why the study?
The study aimed to analyze risk factors for cardiac arrhythmias related to disease factors by evaluating ventricular repolarization parameters on ECG in celiac disease.
Do ventricular repolarization parameters differ between pediatric patients with Celiac Disease and healthy controls?
Case-Control (n=126)
No
Do ventricular repolarization parameters differ between pediatric patients with Celiac Disease and healthy controls?
Answers are grounded in this paper and cite their sources.
Pediatric patients with celiac disease on a gluten-free diet do not show significant differences in overall ventricular repolarization parameters compared to healthy controls, but late diagnosis may be associated with prolonged QTc dispersion.
At the present study, study we aimed to analyze the risk factors for cardiac arrhythmias related disease factors by evaluating some ventricular repolarization parameters in the electrocardiographic (ECG) evaluation of CD. The study was conducted retrospectively from the files of the patients. The ECG evaluation of 63 patients aged 5-18 years diagnosis with CD and 63 healthy control group in Adana City Training and Research Hospital, between 01.2018-11.2022. Patients who were taking any drugs, who had a chronic disease and/or abnormal tests (vitamin B12, folate, tissue transglutaminase, anti-endomysium antibody titers) were excluded from the study. The ventricular repolarization parameters (QT interval, QTc interval, QT dispersion, QTc dispersion, Tp-e interval, Tp-e/QT, Tp-e/QTc) analyzed on ECG and compared both groups. The measured ventricular repolarization parameters of the patients and control groups were not statistically different. From the ECG data, it was found that the QTc min value was higher in patients diagnosed before 5 years old than the patients diagnosed after 8 years old. While the QTc dispersion was higher in patients diagnosed after 8 years old than the patients with an age at diagnosed before 5 years old. It was found that the values of QT min, QT max, and QT in the ECG were influenced by the duration of the disease and significantly high related with the disease duration (more than 5 years). We found that QTc dispersion was higher in patients with a later diagnosis. This suggests that cardiac involvement is also increased in patients with a late diagnosis.
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Taşkın et al. (2023) conducted a case-control in Celiac Disease (n=126). Celiac Disease vs. Healthy controls was evaluated on QTc dispersion (ms) (p=0.377). Ventricular repolarization parameters did not differ significantly between children with diet-compliant celiac disease and healthy controls, though QTc dispersion was prolonged in patients diagnosed at an older age.
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