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January 6, 2015International Journal of Medical and Pharmaceutical Case ReportsOpen Access

Torsades De Pointes Induced by Methadone and Clonazepam Use

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Key result

Combined use of methadone and clonazepam can induce Torsades de Pointes.

Authors

TGTamara Beres Lederer GoldbergFundação de Apoio à Universidade Federal de São Paulo IMIlir MarajGreenwich Hospital AMAlina MastersSUNY Downstate Health Sciences University

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Implication

May prompt QT monitoring with methadone-clonazepam co-use; case-level evidence leaves open prospective confirmation.

Cite This Study

Goldberg et al. (2015) studied this question. Combined use of methadone and clonazepam can induce Torsades de Pointes.

synapsesocial.com/papers/6a89b4feb4e829b19bd45be0 https://doi.org/10.9734/ijmpcr/2015/13517

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Increased Cardiac Risk in Concomitant Methadone and Diazepam Treatment: Pharmacodynamic Interactions in Cardiac Ion Channels2010 · 43 citations
2Effects of Methadone on QT‐Interval Dispersion2005 · 87 citations
3Drug induced QT prolongation and torsades de pointes2003 · 971 citations
4Prospective Study of QTc Changes Among Former Opiate Addicts Since Admission to Methadone Maintenance Treatment2013 · 14 citations
5A double‐blind, randomized, parallel group study to compare the efficacy, safety and tolerability of slow‐release oral morphine versus methadone in opioid‐dependent in‐patients willing to undergo detoxification2009 · 21 citations