Simple and Chemoselective Synthesis of Ketones From Carboxylic Acids and Grignard Reagents Using Dichlorotriphenylphosphorane

Dichlorotriphenylphosphorane was found to be a good condensation reagent for synthesis of ketones from carboxylic acids and Grignard reagents under mild conditions. Synthetic utility of the present method is demonstrated by the chemoselective reaction of carboxylic acids possessing such a functional group as halogen, cyano, or carbonyl.