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August 28, 2006Antimicrobial Agents and ChemotherapyOpen Access

A Novel Extended-Spectrum TEM-Type β-Lactamase, TEM-138, from Salmonella enterica Serovar Infantis

Chedly Chouchani Renaud Berlemont Afef Masmoudi Moreno Galleni Jean‐Marie Frère Omrane Belhadj Kamel Ben‐Mahrez

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Abstract

A novel natural TEM beta-lactamase with extended-spectrum activity, TEM-138, was identified in a ceftazidime-resistant clinical isolate of Salmonella enterica serovar Infantis. Compared to TEM-1, TEM-138 contains the following mutations: E104K, N175I, and G238S. The bla(TEM-138) gene was located on a 50-kb transferable plasmid. Expression studies with Escherichia coli revealed efficient ceftazidimase and cefotaximase activities for TEM-138.

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Chouchani et al. (2006) studied this question.

synapsesocial.com/papers/6a89b6a0991508d05dc99691 https://doi.org/10.1128/aac.00388-06

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