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A comparative study of lactogen receptors in lactogenic hormone-dependent (Nb2-11C) and independent (Nb2-SP) rat lymphoma cell lines revealed no significant differences in their binding and structural characteristics. The affinity for human growth hormone (hGH) and ovine prolactin is identical (Kd = 1.3 X 10(-10) M). Exposure to hGH results in a rapid receptor down-regulation. This process is faster in Nb2-SP cells, however, similar receptor levels are reached within 3 h. Affinity labeling revealed 2 major binding species (Mr 75,000 and 29,000) in both cell lines. These observations suggest that the spontaneous proliferation of Nb2-SP cells probably results from an aberration in some post-receptoral event of the mitogenic pathway.
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Ashkenazi et al. (1987) studied this question.
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