Why the study?
Does cilnidipine alter cardiovascular hemodynamics and sinus automaticity in chronic atrioventricular block dogs?
Does cilnidipine alter cardiovascular hemodynamics and sinus automaticity in chronic atrioventricular block dogs?
Cilnidipine decreases blood pressure and sinus automaticity in an in vivo hypertensive dog model with increased adrenergic tone.
Answers are grounded in this paper and cite their sources.
Cilnidipine may lower BP and sinus automaticity in adrenergic-driven canine AV block models; leaves open translation to human hemodynamics.
Cardiovascular effects of cilnidipine, a dual L/N-type Ca2+ channel blocker, were evaluated in the chronic atrioventricular block dogs, of which systemic blood pressure and plasma catecholamine levels significantly increased in the pre-drug control. Administration of antihypertensive doses of cilnidipine (1 and 3 microg/kg, i.v.) significantly decreased the total peripheral vascular resistance, mean blood pressure, and atrial rate and increased the cardiac output. These results suggest that cilnidipine not only decreases the blood pressure, but also decreases the sinus automaticity in the in vivo hypertensive condition with increased adrenergic tones.
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Takahara et al. (2004) studied this question.
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