Why the study?
Does SIV/SMM replication differ in monocytes and CD4+ T cells between sooty mangabeys and rhesus macaques?
Does SIV/SMM replication differ in monocytes and CD4+ T cells between sooty mangabeys and rhesus macaques?
In vitro differences in SIV replication and CD8+ T cell suppression in monocytes may relate to the asymptomatic state of sooty mangabeys versus the disease-susceptible state of rhesus macaques.
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Highlights monocyte CD8+ inhibition as possible basis for SIV tolerance in mangabeys; leaves open translation to human HIV models.
Monocytes from SIV/SMM infected sooty mangabeys and rhesus macaques were incubated in vitro with live SIV/SMM. The reverse transcriptase (RT) activity in the supernatant fluids of the monocyte cultures of the former species was higher than the RT activity in the latter species. No differences were found in the supernatant fluid of similar cultures of CD4+ T cells from both these species. Autologous (but not allogeneic) CD8+ T cells from SIV infected mangabeys and rhesus macaques inhibited SIV replication in vitro. The suppression appeared more marked in monocytes from the mangabey species. These in vitro differences may relate to the clinically asymptomatic state of the sooty mangabeys and the disease-susceptible state of the rhesus macaques.
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Yehuda‐Cohen et al. (1990) studied this question.
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