Two placental enzyme systems that catalyze the transfer of hydrogen from reduced triphosphopyridine nucleotide to diphosphopyridine nucleotide in the presence of 17β-estradiol have been separated by chromatography on hydroxyapatite. One effects a substrate (17β-estradiol)-mediated transhydrogenation in the presence of DPN- and TPN-linked 17β-estradiol dehydrogenase activities and is completely inhibited by 1.67 M NaCl. The other is a 17β-estradiol-dependent transhydrogenase unassociated with 17β-estradiol dehydrogenase activities; its activity is increased 2.5 times in the presence of 1.67 M NaCl.
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Karavolas et al. (1966) studied this question.
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