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Abstract δ‐Aminolevulinic acid (ALA), labeled with 13C at position 1, 2, 3, 4, or 5, was synthesized from 13C‐labeled glycine, Meldrum's acid, or bromoacetate. The latter compounds were prepared from 13C‐sodium acetate or 13C‐acetic acid. Enzymatic transformation from ALA to porphobilinogen (PBG) was directly observed by 13C‐NMR.
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Kurumaya et al. (1989) studied this question.
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