No anomer discrimination: Concanavalin A (Con A) binds branched 6I-(α- and 6I-(β-D-mannopyranosylthioureido)cyclomaltoheptaoses with the same efficiency (see picture), in contrast with the known lectin specificity for the α anomer in the O-mannopyranosyl series. In addition, the presence of the cyclodextrin core slightly improves the binding efficiency. Unexpectedly, the heptakis(6-mannopyranosylthioureido)-β-cyclodextrins are not recognized. Reverse (6I→6)-linked thioureidomannosyl ligands are only weakly bound. These results underline the influence of the spatial organization of saccharide epitopes on the functional affinity of glycoclusters.
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Baussanne et al. (2001) studied this question.
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