Although various growth factors initiate angiogenesis under pathological circumstances, vessel growth in physiological conditions (e.g., development, training) is related to increased blood flow. This article stresses the role of blood flow in the stimulation of capillary growth in skeletal muscles and in the heart. Also discussed are various components (blood pressure, wall tension, shear stress, blood cells-endothelium interaction) possibly involved in angiogenesis.
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O Hudlická (1988) studied this question.