Supramolecular Control of Oligosaccharide–Protein Interactions: Switchable and Tunable Ligands for Concanavalin A Based on β‐Cyclodextrin

The ins and outs of binding: Supramolecular control of carbohydrate–protein interactions has been achieved through the design of β-cyclodextrin (βCD) based conjugates whose conformation is dependent on a reversible self-inclusion process. The accessibility of glycoligands to the lectin binding site is then regulated by allosteric inclusion of effector/antagonist-like molecules in the βCD cavity (see scheme).