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Cationic specificity determinants of substrate mimetics 1 bind optimally to the binding site of highly specific proteases that normally determines their primary specificity. This designed imitation not only allows trypsin-catalyzed nonspecific and irreversible peptide-bond formation, but now also the use of thrombin and especially the cystein protease clostripain, which acts as the most efficient peptide ligase.
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Bordusa et al. (1997) studied this question.
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