A convenient synthesis of 4‐amino‐3,5‐dialkyl‐4H‐1,2,4‐triazoles

Ester tert‐butoxycarbonylhydrazones 2 were reacted with some carboxylic acid hydrazides to give 4‐terrtutoxycarbonylamino‐3,5‐dialkyl‐4H‐1,2,4‐triazoles 3–6. Treatment of 3–5 with 6 N hydrochloric acid under mild conditions resulted in the formation of 4‐ammo‐3,5‐dialkyl‐4H‐1,2,4‐triazole hydrochlorides 7–9 in good yields. Compound 7a was converted to the free 4‐amino compound 10a upon treatment with ethanolic sodium ethoxide solution.