Position altered! 2-(4,7-Dihydroindolyl) methanamine derivatives (up to >99 % ee) are synthesized by a chiral phosphoric acid catalyzed enantioselective Friedel–Crafts reaction of 4,7-dihydroindoles with imines. A one-pot procedure including the asymmetric Friedel–Crafts alkylation and an oxidation of products with p-benzoquinone leads to 2-indolyl methanamine derivatives in excellent ee values.
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Kang et al. (2008) studied this question.
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