Congenital fibrinogen disorder may be either afibrinogenemia / hypofibrinogenemia / dysfibrinogenemia. Afibrinogenemia may present at birth as bleeding from umbilical cord. Patients with hypofibrinogenemia may present only during surgical intervention or during pregnancy. Pregnancy with this condition is associated with a very high incidence of abortion & abruption. Fibrinogen replacement can be done using either cryoprecipitate or fibrinogen concentrate. Successful pregnancies have been reported using cryoprecipitate & fibrinogen concentrate (FC). We report a woman with 6 abortions previously who was treated with fibrinogen replacement therapy & delivered a live child.
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Chitra et al. (2014) studied this question.
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