Hemolytic-Uremic Syndrome

IN 1955 Gasser and his associates1 introduced the term hemolytie-uremic syndrome to describe 5 children with a fatal disease characterized by acute renal failure, hemolytic anemia and thrombocytopenia. They considered that the severe renal disease distinguished the disorder in their patients from the disorder called thrombotic thrombocytopenic purpura by Moschcowitz2 and microangiopathy by Symmers.3 The coincidence of acute renal failure, hemolytic anemia and thrombocytopenia has subsequently been presented in the pediatric literature as the "hemolytic-uremic syndrome."4 5 6 7 8 9 Most authors have distinguished their patients from those with thrombotic thrombocytopenic purpura or necrosis of the renal cortex although the differential criteria often have . . .