Thrombotic Thrombocytopenic Purpura

Editorial1 September 1950THROMBOTIC THROMBOCYTOPENIC PURPURAP. W. C.P. W. C.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-33-3-739 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFulminating purpura hemorrhagica with profuse bleeding often presents an extremely difficult problem both as to diagnosis and treatment. Much remains to be learned about the hemorrhagic diseases, and the recent differentiation of a new clear-cut clinical and pathologic entity among the cases of "idiopathic" thrombocytopenic purpura marks a welcome advance in our knowledge of these conditions.The first adequate report of the pathologic lesions in this disease is credited to Moschcowitz,1who described multiple hyaline thrombi in the terminal arterioles and capillaries, widely disseminated but most abundant in the myocardium. This was in a girl of 16 who died after...1 Moschcowitz E: An acute febrile pleiochromic anemia with hyaline thrombosis of the terminal arterioles and capillaries: an undescribed disease, Arch. Int. Med. 36: 89-93, 1925. CrossrefGoogle Scholar2 BaerKlempererSchifrin GPA: An acute febrile anemia and thrombocytopenic purpura with diffuse platelet thromboses of capillaries and arterioles, Tr. A. Am. Phys. 51: 43-57, 1936. Google Scholar3 Engel GL: Acute febrile anemia and thrombocytopenic purpura with vasothromboses, Ann. Int. Med. 26: 919-933, 1947. LinkGoogle Scholar4 SingerMotulskyShanberge KAGJN: Thrombotic thrombocytopenic purpura. II. Studies on the hemolytic syndrome in this disease, Blood 5: 434-448, 1950. CrossrefMedlineGoogle Scholar5 BrownNorman EBJW: Multiple platelet thrombi (clinico-pathologic conference), New York State J. Med. 46: 2167-2173, 1946. MedlineGoogle Scholar6 Gore I: Disseminated arteriolar and capillary platelet thrombosis. A morphologic study of its histogenesis, Am. J. Path. 26: 155-167, 1950. MedlineGoogle Scholar7 Muirhead EE: Diffuse platelet thrombosis with thrombocytopenia and hemolytic anemia (thrombotic thrombocytopenic purpura), Am. J. Clin. Path. 18: 523-532, 1948. CrossrefMedlineGoogle Scholar8 FitzgeraldAuerbachFrame PJOE: Thrombocytic acroangiothrombosis (platelet thrombosis of the capillaries, arterioles and venules), Blood 2: 519-541, 1947. CrossrefMedlineGoogle Scholar9 Adams RD: The neuropathological aspects of thrombocytic acroangiothrombosis. A clinico-anatomical study of generalized platelet thrombosis, J. Neurol., Neurosurg. and Psychiat. 11: 27, 1948. CrossrefGoogle Scholar10 GreenRosenthal MAS: Generalized platelet thrombosis. Report of three cases with necropsy findings, J. Mount Sinai Hosp. 16: 110-120, 1949. MedlineGoogle Scholar11 ErichSifter WEJ: Thrombotic thrombocytopenic purpura caused by iodine, Arch. Path. 47: 447-449, 1949. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTHROMBOTIC THROMBOCYTOPENIC PURPURA (MOSCHCOWITZ'S DISEASE): REPORT OF A CASE WITH REMISSION AFTER SPLENECTOMY AND STEROID THERAPY*HENRY D. SHAPIRO, M.D., DAVID DOKTOR, M.D., JACOB CHURG, M.D.Thrombotic thrombocytopenic purpura occurring in pregnancyTHROMBOTIC THROMBOCYTOPENIC PURPURA*WAVERLY S. GREEN JR., M.D., THOMAS W. GREEN, M.D.Thrombotic thrombocytopenic purpuraThrombotic Thrombocytopenic Purpura 1 September 1950Volume 33, Issue 3Page: 739-743KeywordsArteriolesCapillariesHemorrhageIdiopathic thrombocytopenic purpuraLesionsMetastasisMyocardiumThrombotic thrombocytopenic purpura ePublished: 1 December 2008 Issue Published: 1 September 1950 PDF downloadLoading ...