Angiotensin-(1-7) may modulate eNOS activity through interactions involving caveolin 3 and heat shock protein 90.
Hypothesis-generating for eNOS regulation in hypertension; prospective studies needed before clinical translation.
Cardiovascular Actions of Angiotensin-(1-7) 1139in caveolin 3 expression and a decrease in heat shock protein 90.28 These 2 alterations may lead to a decrease in eNOS activity because caveolin 3 prevents calmodulin interaction with NOS, and heat shock protein 90 acts as a scaffold protein to recruit protein kinase B (AKT) to the eNOS complex 35 Hypertension
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Robson A.S. Santos (2014) studied this question.
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