Inhibition of Fibril Formation of Aβ by Guanidiniocarbonyl Pyrrole Receptors

Choosing the target. Inhibition of the formation of β-amyloid fibrils, formed by self assembly from the amyloid β-peptide (Aβ) is an attractive target for the treatment of Alzheimer's disease. Artificial receptors such as 1, specifically designed for Aβ's C-terminal VVIA sequence, are capable in vitro of selectively inhibiting fibril formation of Aβ (1–42) but not of Aβ (1–40), which lacks that specific C-terminal target sequence.