The "standard" heat-clot method of London and Marymont is shown here to be applicable to the determination of creatinine. With this method creatinine can be assayed in very small quantities of serum, and only a conventional laboratory reagent, alkaline picrate, is required. A new fast technic has been developed in which extraction of the clot is carried out for only 10 min. at a high temperature. In addition, the heat-clot method used in conjunction with Lloyd's reagent lends itself to the determination of "true" creatinine values.
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London et al. (1967) studied this question.