Studies on Desoxyribonuclease in Systemic Lupus Erythematosus. Non-Participation of Serum Desoxyribonuclease in the “L.E. Phenomenon” 1

In 1948, Hargraves, Richmond, and Morton (1) described a new cellular element in the bone marrow of patients with acute systemic lupus erythematosus. This element, referred to as the cell, has been confirmed by a number of investigators, and has been suggested as a diagnostic aid (2). The L.E. cell may be formed during the incubation of normal homologous or heterologous leucocytes (3) with the sera of some patients suffering