Fermented Inonotus obliquus Inhabit Proliferation of Hepatocellular Carcinoma HepG2 Cells through inducing Apoptosis and G0/G1 Cell Cycle Arrest

Inonotus obliquus have many pharmacological effects. The aim of this study was to evaluate the effect of fermented Inonotus obliquus (FIO) on hepatocellular carcinoma HepG-2 cells and preliminarily study on possible mechanism. The contents of polysaccharides, terpenoids and polyphenols in unfermented Inonotus Obliquus (UIO) and FIO were determined and he effect of on hepatocellular carcinoma HepG-2 cells was determined. Compared with UIO, the contents of polysaccharides, polyphenols and terpenoids of FIO were significantly increased (P<0.01). FIO significantly inhibited the proliferation of HepG-2 cells and induced HepG-2 apoptosis. The mechanism may be through increased the ratio of G0/G1 phase was (P<0.05) and increase the expression of Cytochrome C and Caspase-3 apoptotic proteins.