Comparison of lidocaine, xylazine, and xylazine/lidocaine for caudal epidural analgesia in horses

Summary Caudal epidural analgesia was achieved in 6 adult horses on 3 successive occasions at weekly intervals by injection of lidocaine, xylazine, and a combination of lidocaine/xylazine through indwelling epidural catheters. Analgesia was defined as a lack of response to pinprick and hemostat pressure in the skin of the perineal area. A significant (P < 0.05) difference was not found for time of onset of analgesia between lidocaine (4.3 ± 0.8 minutes, mean ± SEM) and the lidocaine/xylazine combination (5.3 ± 1.3 minutes). Time to onset of analgesia after administration of xylazine was significantly (P < 0.05) longer (32.0 ± 3.4 minutes) than that for either of the other 2 treatments. Duration of analgesia was significantly (P < 0.05) longer for the combination (329.8 ± 6.2 minutes) than for either drug used alone (lidocaine, 87.2 ± 7.5 minutes; xylazine, 204.2 ± 12.9 minutes). Pulse and respiratory rates were not significantly altered by any of the drugs. Neurologic sequelae were not clinically apparent after administration of the drugs or after chronic epidural catheterization.