What question did this study set out to answer?

To determine whether escalating radiation dose to the cribriform plate region reduces local recurrence and improves survival in patients with medulloblastoma.

August 1, 1984CancerOpen Access

Radiation for medulloblastoma adjusted to prevent recurrence to the cribriform plate region

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To determine whether escalating radiation dose to the cribriform plate region reduces local recurrence and improves survival in patients with medulloblastoma.
Modified standard radiation therapy to increase radiation delivery to the cribriform plate region.
Evaluated 15 consecutive patients (10 with localized Groups I–II disease and 5 with disseminated Groups III–IV disease) with a median follow-up of 32 months, comparing outcomes to a historical cohort of 40 patients.
Disease-free survival was achieved in 8 of 10 (80%) patients with localized disease compared with 7 of 17 (41.2%) in the historical comparison group.
Disease-free survival was achieved in 3 of 5 (60%) patients with disseminated disease compared with 0 of the historical cohort.
No adverse side effects attributable to the modified radiation therapy technique were observed.

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Implication

Cohort study demonstrates improved disease-free survival with increased cribriform plate radiation in medulloblastoma, suggesting routine adoption prevents regional relapse.

Cite This Study

Jereb et al. (1984) studied this question.

synapsesocial.com/papers/6a8a4ac55246293882fd7ea7 https://doi.org/10.1002/1097-0142(19840801)54:3<602::aid-cncr2820540336>3.0.co;2-y

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Implication

Cohort study demonstrates improved disease-free survival with increased cribriform plate radiation in medulloblastoma, suggesting routine adoption prevents regional relapse.

Radiation for medulloblastoma adjusted to prevent recurrence to the cribriform plate region

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Discussion

Implication

Cite This Study

Radiation for medulloblastoma adjusted to prevent recurrence to the cribriform plate region

Key Points

Discussion

Implication

Cite This Study

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