Effective diagnosis of multiple disease markers is a central challenge in biosensing. The authors describe a prototype lab-on-a-chip sensor that can simultaneously detect three distinct disease markers, in six combinations. This involves cascaded transmission of light through the chip via weak coupling between engineered modes, yielding a detailed spectral fingerprint to extend traditional resonance-shift techniques. These principles for the design of multiplexing photonic-crystal biosensors could be significant for tomorrow's medical diagnostics.
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Al-Rashid et al. (2015) studied this question.
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