An improved solid‐phase synthesis of a difficult‐sequence peptide using hexafluoro‐2‐propanol

The polar solvent 1,1,1,3,3,3‐hexafluoro‐2‐propanol was used, diluted with dichloromethane, to improve the extent and time of aminoacylation and acetylation in the solid‐phase synthesis of a difficult‐sequence peptide (the d‐Ala17 analog of the human gonadotropin‐releasing hormone precursor peptide fragment 14‐36) which characteristically exhibits chronic repetitive incomplete peptide bond formation.