Nitric Oxide Synthesis in Meningococcal Meningitis

Letters15 February 1994Nitric Oxide Synthesis in Meningococcal MeningitisJelle J. Visser, PhD, Rob J. P. M. Scholten, MD, and Klaas Hoekman, MDJelle J. Visser, PhDFree University Hospital; 1007 MB Amsterdam; The NetherlandsSearch for more papers by this author, Rob J. P. M. Scholten, MDFree University Hospital; 1007 MB Amsterdam; The NetherlandsSearch for more papers by this author, and Klaas Hoekman, MDFree University Hospital; 1007 MB Amsterdam; The NetherlandsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-4-199402150-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Clinical meningitis arises largely from the inflammatory response to bacteria invading the cerebrospinal fluid. Because nitric oxide, an endogenous mediator with vasodilator, neurotransmitter, and cytotoxic activities may be involved [1], we measured cerebrospinal fluid levels of nitrate and nitrite, the stable degradation products of nitric oxide, in 94 patients with meningococcal meningitis and in 44 patients with noninflammatory neurologic disease.Controls had mean cerebrospinal fluid nitrate levels of 6.3 µmol/L (range, 2.3 to 17.3 µmol/L) and nitrite levels of 0.5 µmol/L (range, 0.4 to 1.7 µmol/L). Compared with controls, patients with meningitis had a mean nitrate level ...References1. Moncada S, Palmer RM, Higgs EA. Nitric oxide: Physiology, pathophysiology, and pharmacology. Pharmacol Rev. 1991; 43:109-42. Google Scholar2. Marletta MA, Yoon PS, Iyengar R, Leaf CD, Wishnok JS. Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate. Biochemistry. 1988; 21:8706-11. Google Scholar3. Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEB J. 1992; 6:3051-64. Google Scholar4. Dawson TM, Dawson VL, Snyder SH. A novel neuronal messenger molecule in the brain: the free radical, nitric oxide. Ann Neurol. 1992; 32:297-311. Google Scholar Author, Article, and Disclosure InformationAffiliations: Free University Hospital; 1007 MB Amsterdam; The Netherlands PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByLipid A-activated inducible nitric oxide synthase expression via nuclear factor-κB in mouse choroid plexus cellsNitric Oxide-Induced Neuronal to Glial Lineage Fate-Change Depends on NRSF/REST Function in Neural Progenitor CellsTwo centuries of meningococcal infection: from Vieusseux to the cellular and molecular basis of diseaseRole of Nitric Oxide as Mediator of Nerve Injury in Inflammatory NeuropathiesRapid Diagnosis of Bacterial Meningitis Using Nitrite Patch TestingRole of Nitric Oxide on the Blood–Brain and Spinal Cord BarriersConcentrations of Inducible Nitric Oxide Synthase (iNOS) and Neuronal Nitric Oxide Synthase (nNOS) in Cerebrospinal Fluid of Patients With Severe Head InjuriesNitric oxide metabolite determinations reveal continuous inflammation in multiple sclerosisNitric oxide levels in rat cortex, hippocampus, cerebellum, and brainstem after impact acceleration head injuryNO as a signalling molecule in the nervous systemA critical evaluation of the brain efflux index method as applied to the nitric oxide synthase inhibitor, aminoguanidineNitric Oxide (NO) metabolism in the cerebrospinal fluid of patients with severe head injuryN ω -nitro-L-arginine methyl ester (L-NAME) attenuates the acute inflammatory responses and brain injury during the early phase of experimental Escherichia coli meningitis in the newborn pigletIncreased intrathecal nitric oxide formation in multiple sclerosis; cerebrospinal fluid nitrite as activity markerQuantification of iNOS mRNA with Reverse Transcription Polymerase Chain Reaction Directly from Cell LysatesOxidative Stress in Bacterial MeningitisNitric oxide and prostaglandin E2 formation parallels blood–brain barrier disruption in an experimental rat model of bacterial meningitisThe Role of Glial Nitric Oxide in Neurotoxicity and Central Nervous System DiseasesChapter 16 Nitric oxide and carbon monoxide in the brain pathology of heat stressRegulation of the Cerebral Circulation: Role of Endothelium and Potassium Channels7-Nitroindazole Inhibits Pial Arteriolar Vasodilation in a Rat Model of Pneumococcal MeningitisPlasma nitrogen oxides and blood lactate concentrations in Ghanaian children with malariaRoles of proinflammatory and anti-inflammatory cytokines in pathophysiology of bacterial meningitis and effect of adjunctive therapyCerebrospinal fluid and plasma nitrite and nitrate concentrations after head injury in humansNitric oxide neurotoxicityInhibition of nitric oxide synthase attenuates blood-brain barrier disruption during experimental meningitisPharmacological characterization of nitric oxide production in a rat model of meningitisNITRIC OXIDE SYNTHASE: Role as a Transmitter/Mediator in the Brain and Endocrine SystemPneumococcal cell wall components induce nitric oxide synthase and TNF-α in astroglial-enriched culturesNitric Oxide Actions in the Nervous SystemAn Inflammatory Role for Nitric Oxide during Experimental Meningitis in the RatExpression of Inflammatory Cytokines and Inducible Nitric Oxide Synthase in Brains of SIV-Infected Rhesus Monkeys: Applications to HIV-Induced Central Nervous System DiseaseNitric oxide production in bacterial meningitis.Inhibition of nitric oxide synthase partially attenuates alterations in the blood-cerebrospinal fluid barrier during experimental meningitis in the ratPhysiological and Toxicological Actions of Nitric Oxide in the Central Nervous SystemREVIEW ■ : Nitric Oxide: Actions and Pathological RolesNitric Oxide in Bacterial Meningitis 15 February 1994Volume 120, Issue 4Page: 345-346KeywordsCerebrospinal fluidEndothelial cellsMeningitisMeningococcal diseaseNeisseria meningitidisNeuronsNeurotransmittersNitratesNitric oxideVasodilators Issue Published: 15 February 1994 CopyrightCopyright © 1994 by American College of Physicians. 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