Nitrone-Modified Gold Nanoparticles: Synthesis, Characterization, and Their Potential as 18 F-Labeled Positron Emission Tomography Probes via I-SPANC

High Resolution Image Download MS PowerPoint Slide A novel bioorthogonal gold nanoparticle (AuNP) template displaying interfacial nitrone functional groups for bioorthogonal interfacial strain-promoted alkyne–nitrone cycloaddition reactions has been synthesized. These nitrone–AuNPs were characterized in detail using 1 H nuclear magnetic resonance spectroscopy, transmission electron microscopy, thermogravimetric analysis, and X-ray photoelectron spectroscopy, and a nanoparticle raw formula was calculated. The ability to control the conjugation of molecules of interest at the molecular level onto the nitrone–AuNP template allowed us to create a novel methodology for the synthesis of AuNP-based radiolabeled probes.