Preclinical study demonstrates preserved morphology and exercise tolerance despite lifelong NAD depletion in muscle models, suggesting NAD loss does not drive muscle aging.
abundance while maintaining tissue integrity and functionality, as demonstrated by preserved muscle morphology, contractility, and exercise tolerance. This absence of functional impairments was further supported by intact mitochondrial respiratory capacity and unaltered muscle transcriptomic and proteomic profiles. Furthermore, lifelong NAD depletion did not accelerate muscle aging or impair whole-body metabolism. Collectively, these findings suggest that NAD depletion does not contribute to age-related decline in skeletal muscle function.
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Chubanava et al. (2025) studied this question.
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