Regulation of the Cell Cycle by Diethylstilbestrol and Progesterone in Cultured Endometrial Cells

Cultures of primary explanted rabbit endometrium epithelial cells were found to be a mixture of dividing or cycling (20%) and non-dividing or GO (80%) cells. The addition of diethylstilbestrol had the effect of switching most of the GO cells into the cell cycle and to shorten the length of the cell cycle through a shortening of G1 and S. Progesterone had the opposite effects.