Why the study?
Understanding interactions among cell types in the tumor microenvironment can suggest innovative therapeutic strategies for colorectal cancer progression and metastasis.
Does disruption of the FGF19/ANGPTL4 axis reduce colorectal cancer liver metastasis in preclinical models?
Population
CRC metastatic mouse models and clinical samples from patients with CRCLM
Comparison
Disruption of the FGF19/ANGPTL4 axis vs control
Design
Preclinical translational and mouse model study
Authors
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FGF19-mediated TME interactions may inform future CRC metastasis therapies; leaves open clinical translation pending validation.
Does disruption of the FGF19/ANGPTL4 axis reduce colorectal cancer liver metastasis in preclinical models?
The FGF19/ANGPTL4 axis plays a crucial role in colorectal cancer liver metastasis, and its disruption offers a novel therapeutic strategy.
Fan et al. (2024) studied this question.
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