New Sensitive lmmunoradiometric Assays for Thyrotropin

Editorials1 May 1986New Sensitive lmmunoradiometric Assays for ThyrotropinDOUGLAS S. ROSS, M.D.DOUGLAS S. ROSS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-5-718 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThyrotropin (TSH) is the pituitary hormone that regulates thyroid hormone production; thyroid hormone feedback to the pituitary gland suppresses the secretion of thyrotropin. Since the 1970s, an elevated serum thyrotropin concentration measured by radioimmunoassay (RIA) has been used to discriminate between primary hypothyroidism and euthyroidism. Patients with early thyroid failure (subclinical hypothyroidism) have elevations in serum thyrotropin levels before serum thyroxine levels fall below the normal range. In patients with hyperthyroidism, thyrotropin should be suppressed; however, conventional thyrotropin-RIA methods have detection limits of 1 to 2 µIU/mL, whereas euthyroid persons frequently have serum thyrotropin concentrations of below 1 µIU/mL. Modified...References1. ALLENWATSON KD. Thyrotropin as the initial screening test for thyroid disease [Letter]. Clin Chem. 1984;30:502-3. CrossrefMedlineGoogle Scholar2. COBBLAMBERTONJACKSON WRI. Use of a rapid, sensitive immunoradiometric assay for thyrotropin to distinguish normal from hyperthyroid subjects. Clin Chem. 1984;30:1558-60. CrossrefMedlineGoogle Scholar3. CALDWELLKELLETTGOW GHS. A new strategy for thyroid function testing. Lancet. 1985;1:1117-9. CrossrefMedlineGoogle Scholar4. RAJATANAVINBRAVERMAN RL. Euthyroid hyperthyroxinemia. J Endocrinol Invest. 1983;6:493-505. CrossrefMedlineGoogle Scholar5. RODRIGUEZ-ESPINOSAORDONEZ-LLANOSMORA-BRUGUESLOPEZ-CALULLCORTES-RIUS JJJCM. Sensitive immunoradiometric assay (IRMA) for serum thyrotropin may be insufficient to make the thyrotropin-releasing-factor test unnecessary [Letter]. Clin Chem. 1985;31:1081-2. CrossrefGoogle Scholar6. KIRKEGAARDBREGENGARD CC. Is the TRH test necessary [Letter]? Lancet. 1985;1:222. CrossrefMedlineGoogle Scholar7. MARDELLGAMLENWINTON RTM. High sensitivity assay of thyroid stimulating hormone in patients receiving thyroxine for primary hypothyroidism and thyroid carcinoma. Br Med J [Clin Res]. 1985;290:355-6. CrossrefMedlineGoogle Scholar8. WHITEGERICKE GL. Diagnostic performance of a commercial assay for thyrotropin, when used as the initial test of thyroid function [Letter]. Clin Chem. 1985;31:1914-6. CrossrefMedlineGoogle Scholar9. LARSEN P. Thyroid-pituitary interaction: feedback regulation of thyrotropin secretion by thyroid hormones. N Engl J Med. 1982;306:23-32. CrossrefMedlineGoogle Scholar10. SEMPLESLATERREIDGLEN CSAA. A sensitive immunoradiometric assay for serum thyroid stimulating hormone [Letter]. Br Med J [Clin Res]. 1985;290:69-70. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySERUM THYROID-STIMULATING HORMONE MEASUREMENT FOR ASSESSMENT OF THYROID FUNCTION AND DISEASERadioiodination and quality control of human thyrotropin for radioimmunoassayThe clinician and the thyroidMeasurement of Thyroid FunctionMeasurement of Parathyroid HormoneSerum Thyrotropin and the Assessment of Thyroid StatusDavid A. Ehrmann, MD, David H. Sarne, MDStrategies for Cost-Effective Thyroid Function Testing with Modern MethodsSolitary Thyroid Nodule: Diagnosis and ManagementThyroid DysfunctionProblems with asthma following treatment of thyrotoxicosisImmunoradiometric assay of serum thyroid stimulating hormone (TSH) as a first-line test in a mixed hospital populationResponse of Thyrotropin-Secreting Pituitary Adenomas to a Long-Acting Somatostatin AnalogueLetter to the editorEuthyroid HyperthyroxinemiaThyroid dysfunction during chronic amiodarone therapyHyperthyroidism in the Elderly 1 May 1986Volume 104, Issue 5Page: 718-720KeywordsAttentionHyperthyroidismHypothyroidismPituitary glandProlactinRadioimmunoassaysThyroidThyroid hormonesThyroid-stimulating hormoneThyroxine Issue Published: 1 May 1986 PDF downloadLoading ...