February 20, 1998FEBS Letters

α1‐Syntrophin has distinct binding sites for actin and calmodulin

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Structured PICO

Population

Recombinant alpha1-syntrophin proteins and actomyosin fractions from cardiac and skeletal muscle

Intervention

Overlay and co-sedimentation assays

Outcome

Binding affinity (Kd) and identification of binding sites for F-actin and calmodulinsurrogate

Alpha1-syntrophin acts as an actin-binding protein and binds calmodulin, suggesting a novel role in the dystrophin-glycoprotein complex or other cellular functions.

Authors

YIYuko IwataNational Research Institute of Police Science YPYan PanAnhui University TYTomokazu YoshidaSysmex (Japan)

Discussion

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Implication

Hypothesis-generating for syntrophin’s cytoskeletal role in muscle; leaves open relevance to human cardiomyopathy pending further validation.

Cite This Study

Iwata et al. (1998) studied this question.

synapsesocial.com/papers/6a8a60cb5246293882fd8724 https://doi.org/10.1016/s0014-5793(98)00085-4

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Implication

Hypothesis-generating for syntrophin’s cytoskeletal role in muscle; leaves open relevance to human cardiomyopathy pending further validation.

α1‐Syntrophin has distinct binding sites for actin and calmodulin

Structured PICO

Discussion

Implication

Cite This Study

α1‐Syntrophin has distinct binding sites for actin and calmodulin

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider