In vivo evaluation of the antihyperglycemic potential of Deverra scoparia (Coss. & Durieu), a north African endemic species

Deverra scoparia (D. scoparia) Coss. & Durieu is an endemic plant from North Africa that is commonly utilized in folk medicine for diabetes treatment. This study aimed to evaluate the in vivo antidiabetic effects of D. scoparia in both normal and STZ-induced diabetic rats. The investigation focused on the impact of an aqueous extract of D. scoparia administered at a dosage of 40 mg/kg on glycemia and lipid profiles in these rats. Additionally, the study included assessments of glycogen content in the liver and skeletal muscles (EDL and soleus), as well as a phytochemical analysis. Both single and repeated oral doses of the aqueous extract (40 mg/kg) resulted in a significant decrease in blood glucose, total cholesterol, and triglyceride levels in diabetic rats. Moreover, this extract improved glucose tolerance and enhanced hepatic glycogen content in the diabetic subjects. Notably, the plant exhibited a rich profile of certain phytochemicals, particularly phenolic acids and flavonoids. The findings of this study clearly indicate that the aqueous extract of D. scoparia possesses substantial antidiabetic activity.