Why the study?
Although macrophage miR-155 expression promotes cardiac inflammation, hypertrophy, and failure from pressure overload, its utility as a diagnostic biomarker for HF needed clarification.
Does miR-155 expression serve as a potential diagnostic biomarker for heart failure?
Does miR-155 expression serve as a potential diagnostic biomarker for heart failure?
This systematic review aims to evaluate the potential of miR-155 expression as a diagnostic biomarker for heart failure.
miR-155 may serve as an HF biomarker; supports mechanistic data but requires prospective validation before clinical adoption.
Background: Heart failure (HF) is a complex clinical syndrome with signs and symptoms resulting from any structural dysfunction of ventricular filling or blood ejection. miRNAs were known as essential regulators and tissue-specifically expressed. MicroRNA-155 (miR-155) expression in macrophages is already well known to promote hypertrophy, cardiac inflammation, and failure due to pressure overload. In this study, we aim to identify the role of expression miR-155 as a potential biomarker for HF.
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Tandarto et al. (2023) studied this question.
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