Why the study?
Does chronic quinapril treatment modulate central ACE activity and vasopressin content in rats?
Population
36 rats (n=22 treated, n=14 untreated controls)
Comparison
Quinapril 6 mg/kg body weight per gavage daily… vs Untreated controls
Design
Preclinical
Follow-up
6 weeks
Authors
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Hypothesis-generating for central ACE inhibitor effects in rats; leaves open translation to human cardiovascular therapy.
Does chronic quinapril treatment modulate central ACE activity and vasopressin content in rats?
Chronic oral quinapril suppresses central ACE activity and reduces vasopressin content in brain areas involved in cardiovascular regulation, suggesting a central modulatory mechanism for ACE inhibitors.
Frank Muders (1997) studied this question.
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