Familial haemorrhagic strokes can be caused by single gene disorders, including factor V deficiency, which affect clotting factors, vascular anomalies, or cause hypertension.
May prompt genetic evaluation in select familial haemorrhagic stroke cases; leaves open prevalence and screening utility.
Strokes may occur with a large number of genetic disorders. Natowicz and Kelley have reviewed the single gene disorders capable of causing familial haemorrhagic strokes. These may be classified into four groups: a) hereditary disorders affecting clotting factors or platelets; b) hereditary disease producing vascular anomaly; c) hereditary disease causing hypertension and d) miscellaneous group including neurofibromatosis, sickle cell disease and tuberous sclerosis.
No takes yet. Share an insight, caveat, or question.
Wadia et al. (1992) studied this question.
Synapse has enriched one closely related paper. Consider it for comparative context: